Curriculum Vitae
Biomedical scientist, editor and scientific advisor with more than two decades of experience discovering and developing recombinant proteins, nanoparticles and viral vector-based therapeutics for cancer, autoimmune bleeding disorders, blast-induced traumatic brain injury and nerve agent exposure — and advising federal agencies on medical countermeasures for chemical, biological and blast threats.
Download PDFSelected Impact
246-page
scientific report on blast overpressure and brain injury
250+
laboratories received shared plasmid expression vectors via Addgene
U.S. Patent
5,965,393 — recombinant baculovirus expression system
Multiple
peer-reviewed research publications
Multiple
scientific awards and recognitions
Appointments
Brain Research Scientist
Cognosante / AFS, Fort Detrick, MD
Subject matter expert on blast injury and medical countermeasures; authored executive summaries, charters and annual reports for senior government leadership.
Associate Editor
Frontiers in Cell & Developmental Biology and Frontiers in Molecular Biosciences
Managed peer review and final publication decisions for nearly 100 manuscripts; curated research topics in cellular biochemistry.
Program Manager / SME (Vaccines & Test Kits)
Goldbelt, Washington, DC
Technical program manager for large-scale vaccine and diagnostic procurement.
Program Analyst / Senior Scientist
Countering WMD, Department of Homeland Security
Analyzed chemical and biological WMD incident data for CWMD leadership; proposed research directions in detection, trigger technologies and biosurveillance.
Research Investigator
USAMRICD / Alakaina Foundation, Aberdeen Proving Ground, MD
Developed AAV-based gene therapy giving complete prophylactic protection against nerve agents; efficacy, immunogenicity and biodistribution studies.
Research Specialist
Rockefeller University, New York, NY
Laboratory research, experimental design and data analysis.
CEO and Co-Founder
XY Biology Corporation, Shaker Heights, OH
Co-founded and led an early-stage biology venture.
Assistant Professor
Lerner Research Institute, Cleveland Clinic / Case Western Reserve University
Led programs on anti-angiogenic therapy, antiphospholipid syndrome and nanoparticle therapeutics; wrote and submitted research grants.
Research Associate and Instructor
Case Western Reserve University, Cleveland, OH
Cell migration, metastasis and wound healing; discovery of novel alpha kinases.
Postdoctoral Fellow
The Ohio State University, Columbus, OH
Role of the mRNA poly(A) tail in transport and translation.
Postdoctoral Fellow
Institute of Molecular Medicine and Genetics, Medical College of Georgia
Gad65 and Gad67 promoter-regulated transcription in a mouse model system.
Project Associate
National Institute of Immunology, New Delhi, India
Baculovirus enhancer elements and transcriptional regulation; US patent on the resulting expression system.
Selected Publications
Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve gases in mice
Betapudi, V., Goswami, R., Silayeva, L., Doctor, D., Chilukuri, N.
Science Translational Medicine
2020Gene therapy leaves a vicious cycle
Goswami, R., … Betapudi, V. (senior author)
Frontiers in Oncology
2019Novel role for p56/Lck in the regulation of endothelial cell survival and angiogenesis
Betapudi, V., Shukla, M., Alluri, R., Merkulov, S., McCrae, K.R.
FASEB Journal
2016Induction of endothelial cell microparticle release by antiphospholipid antibodies
Betapudi, V., McCrae, K.R.
Blood
2012Distinct roles of non-muscle myosin II isoforms in cancer cell spreading and migration
Betapudi, V., Licate, L., Egelhoff, T.T.
Cancer Research
2006A novel alpha kinase with a vWFA motif in Dictyostelium discoideum
Betapudi, V., Mason, C., Licate, L., Egelhoff, T.T.
Molecular Biology of the Cell
2005Eggshell-bound starch phosphorylase packed bed reactor for continuous production of glucose-1-phosphate
Betapudi, V., Kumar, A.
Journal of Biotechnology
1994
Education
Awards
- Blue Flame AwardAddgene
- Elsa Albrecht Best Research Paper AwardCleveland Clinic · 2009 & 2012
- Chairman’s Award for Art in ScienceCleveland Clinic · 2008
- Best Poster Presentation AwardCell Biology Meeting · 2005 & 2007
- Senior Research Fellowship AwardCouncil of Scientific and Industrial Research, Government of India
Patents
- Method for enhancing foreign gene expression in baculovirus expression vector systemUS Patent 5,965,393 · Sole inventor · 1999
- Method for enhancing foreign gene expression in the baculovirus expression vector systemIndian Patent 112/DEL/97 · Sole inventor · 1997
- Recombinant AAV–Paraoxonase 1 F11 particles for prophylactic protection against G-type nerve agentsUS Provisional 62/475,502 · Sole inventor · 2017
Service
- Associate Editor, Frontiers in Cell and Developmental Biology and Frontiers in Molecular Biosciences
- Plasmid expression vectors shared with more than 250 laboratories via Addgene
- Member, American Medical Writers Association; Life Member, Association of Biotechnology and Pharmacology; American Society for Cell Biology